Cytostatic activity
WebApr 14, 2024 · AbstractPurpose:. Inhibition of monocarboxylate transporter (MCT) 1–mediated lactate transport may have cytostatic and/or cytotoxic effects on tumor cells. We report results from the dose-escalation part of a first-in-human trial of AZD3965, a first-in-class MCT1 inhibitor, in advanced cancer.Patients and Methods:. This multicentre, … WebOct 14, 2004 · Abstract. Angiogenesis is a critical event in tumor growth and metastasis, which can be inhibited by conventional anticancer drugs such as the microtubule-damaging agent paclitaxel (Taxol). In this study, we investigate the mechanism of action of paclitaxel on human endothelial cells. We characterize two distinct effects of paclitaxel on human …
Cytostatic activity
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WebCytostatic definition, inhibiting cell growth and division. See more.
Webcytostatic: [ si″to-stat´ik ] 1. suppressing the growth and multiplication of cells. 2. an agent that so acts. WebAll of the compounds were tested in vitro for cytostatic activity with hormone-independent MDA-MB 231 and hormone-dependent MCF-7 breast cancer cells. A cytostatic effect was found in both cell lines. The comparison of results exhibited a stronger inhibitory effect on MCF-7 cells only for compounds with high binding affinity for the estrogen ...
WebCytostatic and the pro-apoptotic activity of ornithine dendrons/dendrimers determine their anti-tumorigenic potential. To estimate interrelations between their structure and bioactivity two dendrons: cationic, Arg-NO 2 -terminated Dendron 15 and Pro-functionalized Dendron 13 were tested in a U87 glioblastoma cell model ( Figure 3 ). WebSep 1, 2024 · To study the efficiency of CDDP and Elli to inhibit primary Nbl tumor growth, intravasation, and extravasation in the organs, we adapted the in ovo CAM assay …
WebSep 1, 2024 · Noteworthy, such results are most likely caused by a high cytostatic activity of relatively high concentrations (but not high enough to kill the host organism) of both compounds, resulting in a rapid and efficient arrest of cell growth and induction of cell death rather than caused by their antimetastatic activity.
WebMay 1, 2024 · The cytostatic activity of G. robertianum extracts processed by micro- and ultrafiltration was tested on the Hep-2 (human epidermoid carcinoma of larynges) cell … calne community planWebCytostatic activity of selected experimental agents was performed, then compared with the activity of melphalan according to the method of Larsson (1). Cytotoxic drug … calne fishing shopWebcytostatic. 1 of 2 adjective. cy· to· stat· ic ˌsīt-ə-ˈstat-ik. : tending to retard cellular activity and multiplication. cytostatic treatment of tumor cells. cytostatically. -i-k (ə-)lē. adverb. calneh cityWebCytostatic Factor (CSF) is a cytoplasmic factor found in unfertilized eggs of the frog that causes metaphase arrest of cell cycles in the oocyte and zygote. ... CSF-injected zygotes are arrested at metaphase and show morphology and cellular activities strikingly similar to those of unfertilized eggs. Fresh cytosols extracted from unfertilized ... calne express kebabWebMay 24, 2024 · Cytotoxic medications, like chemotherapy drugs, are made to kill cancer cells or keep them from growing. Other cytotoxic substances are found in nature, like venom from some snakes. Your … calne hand car washWebDec 16, 2013 · The 4-N-alkanoylgemcitabines showed potent cytostatic activities in the low nanomolar range against a panel of tumor cell lines, whereas cytotoxicity of the 4-N-alkylgemcitabines were in the low micromolar range. The cytotoxicity for the 4-N-alkanoylgemcitabine analogues was reduced approximately by 2 orders of magnitude in … calne football clubWebJun 25, 2010 · Saponins are natural glycosides which possess a wide range of pharmacological properties including cytotoxic activity. In this review, the recent studies (2005–2009) concerning the cytotoxic activity of saponins have been summarized. The correlations between the structure and the cytotoxicity of both steroid and triterpenoid … calneh biblical meaning