Cyp17a1是什么
WebBackground. CYP17A1, also known as cytochrome P450C17, is a steroidogenic enzyme belonging to the P450 cytochrome superfamily of monooxygenases (1, 2). In humans, CYP17A1 expression is abundantly expressed in the adrenal cortex, where it plays a central role in the androgen synthesis pathway (2). CYP17A1 is the primary target of … WebSep 18, 2024 · cyp17a1基因突变可导致完全或者不完全17a-羟化酶/ 17, 20-裂解酶的缺乏, 临床表现为高血压、低钾血症、外生殖器发育异常。大多数突变位于基因的编码序列, 极少数的突变位于内含子区。本研究旨在探讨一种新型的基因突变, cyp17a1内含子突变对临床表型的 …
Cyp17a1是什么
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WebCYP17A1 是阿比特龙的主要靶标，阿比特龙是一种用于治疗去势抗性前列腺癌 (CRPC) 的合成类固醇 (3, 4)。. 阿比特龙可转化为更具活性的 D4A，D4A 通过抑制 CYP17A1 和其他类固醇激素合成酶来抑制雄激素受体信号转导 (3, 4)。. 这能抑制 5α-双氢睾酮 (DHT) 合成，DHT … WebCyp17a1: Gene Name: Cytochrome P450, family 17, subfamily a, polypeptide 1: Aliases: Cyp17, p450c17: RefSeq: NC_000085.6 NT_039687.8: Ensembl: …
WebDec 7, 2024 · Progesterone-17α-hydroxylase (CYP17A) could transform progesterone to 17α-hydroxyprogesterone (17-HP). The main limitation of 17-HP biological production is the lack of CYP17A or the low activity of existing enzymes. A novel CYP17A1 (BT_CYP17A1) from Bovine taurus was identified by genome mining and heterolo WebJul 30, 2024 · Background 17α-Hydroxylase deficiency is a recessively inherited autosomal disease caused by mutations in the CYP17A1 gene. It is a rare disease and accounts for approximately 1% of congenital adrenal cortex hyperplasias. Inhibition of 17α-hydroxylase causes low levels of cortisol and high levels of adrenocorticotropic hormone in the blood …
WebMay 15, 2024 · Cytochrome P450 17A1 (CYP17A1) is a critical steroidogenic enzyme, essential for producing glucocorticoids and sex hormones. This review discusses the complex activity of CYP17A1, looking at its role in both the classical and backdoor steroidogenic pathways and the complex chemistry it carries out to perform both a … WebThe CYP17A1 gene provides instructions for making a member of the cytochrome P450 enzyme family. Like other cytochrome P450 enzymes, CYP17A1 is involved in the …
WebCYP17A1 is the Branching Point of the Adrenal Steroidogenic Pathway. CYP17A1 is on Chromosome 15q23 and codes a 57 kDa enzyme that catalyzes two oxidase reactions …
WebJan 13, 2015 · Abstract. VT-464 is a novel, nonsteroidal, small-molecule CYP17A1 inhibitor with 17,20-lyase selectivity. This study evaluates the anticancer activity of VT-464 compared with abiraterone (ABI) in castrate-resistant prostate cancer cell lines and xenograft models that are enzalutamide (ENZ)-responsive (C4-2) or ENZ-resistant (MR49C, MR49F). In … greetings in english class细胞色素 P450 17A1（英語：Cytochrome P450 17A1）也被称为甾体17α-单加氧酶（steroid 17α-monooxygenase），17α-羟基化酶（17α-hydroxylase），17,20-碳链裂解酶（17,20-lyase 或 17,20-desmolase）是一种羟基化酶，由位于人类10号染色体的 CYP17A1 基因编码 。这一基因在许多组织与细胞中都有表达，特别是肾上腺皮质的网状带（英语：zona reticularis）和 … greetings in different culturesWeb1 day ago · 【共同社4月13日电】在全球大受欢迎的日本作家村上春树（74岁）的小说新作《城市及其不确定的墙》13日发售。这是继《刺杀骑士团长》（全2册）之后时隔约6年 … greetings informalWebMar 21, 2024 · CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP17A1 include Adrenal Hyperplasia, Congenital, Due To 17-Alpha-Hydroxylase … greetings in email capitalizedWebCYP17A1 is strongly expressed in half about of human prostate carcinomas, implying an intracellular androgen synthesis by cancer cells. Abiraterone effectively blocked nuclear … greetings in filipinoWebJun 11, 2024 · The cytochrome P450 family 17 subfamily A member 1 (CYP17A1) gene, located on chromosome 10q24.3, consists of eight exons and seven introns and is expressed mainly in the adrenal glands and gonads ( 6, 7 ). In humans, CYP17A1 encodes the P450c17 protein, a key enzyme in the steroidogenic pathway. It can catalyze two … greetings in formal emailWebMay 5, 2011 · 2013-11-15 白血病发生与什么基因有关 2024-02-15 基因检测出风险，还能投保么 2015-07-24 肝细胞基因点位检测是什么 2014-04-27 什么是荷尔蒙？ 2014-05-01 … greetings in french dialogue